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US 4,699,880 AGranted
Method of producing monoclonal anti-idiotype antibody
AssigneeImmunomedics, Inc.
InventorNeil I. Goldstein
Life of this patent
Estimating the term…
Abstract
A method for determining the presence of an antigen in a liquid sample. The method includes incubating the sample with an antibody which specifically binds an epitope on the antigen in the presence of a given quantity of an anti-idiotype antibody which specifically binds an epitope on the hypervariable region of the antibody. Also, a method of producing a monoclonal anti-idiotype antibody by fusing lymphocytes from an animal in which a tumor capable of secreting idiotype antibodies has been grown, with myeloma cells.
Claims6
A method of producing a monoclonal anti-idiotype antibody, comprising the steps of:
- (a) fusing lymphocytes from an animal in which a tumor capable of secreting idiotype antibodies has been grown, with myeloma cells;
- and
- (b) isolating and cloning resultant hybridoma cells secreting monoclonal antibodies which specifically bind an epitope on the hypervariable region of said idiotype antibodies.
Dependencies are inferred from the claim text.