Synthetic, plasma-free, transfusible platelet storage medium
AssigneeAmerican Red Cross
InventorStein Holme
Life of this patent
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Abstract
The invention is a sterile, plasma-free platelet storage medium. The platelet storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 7.5 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The platelet storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The platelet storage medium is capable of storing and preserving platelets for at least 10 days.
Claims20
A sterile, plasma-free platelet storage medium comprising:
- a physiologically compatible, aqueous electrolyte solution, one liter of said electrolyte solution having:
- between about 3.0 grams and about 7.5 grams of dextrose;
- between about 3.0 grams and about 6.0 grams of sodium citrate;
- and
- between about 2.0 grams and about 4.2 grams of sodium bicarbonate;
- said platelet storage medium being isotonic and having a pH in a range of between about 6.8 and about 7.4, said platelet storage medium being capable of preserving platelets for at least about 10 days at a temperature of at least about 22.degree. C.
A sterile, plasma-free platelet storage medium consisting essentially of:
- a physiologically compatible, aqueous electrolyte solution, one liter of said electrolyte solution having:
- between about 3.0 grams and about 7.5 grams of dextrose;
- between about 3.0 grams and about 6.0 grams of sodium citrate;
- and
- between about 0.4 gram and about 0.6 gram of citric acid;
- between about 2.0 grams and about 4.2 grams of sodium bicarbonate;
- said platelet storage medium being isotonic and having a pH in a range of between about 6.8 and about 7.4, whereby said platelet storage medium preserves platelets for at least about 14 days at a temperature of at least about 22.degree. C.
A sterile, plasma-free platelet storage medium consisting essentially of:
- distilled water, one liter of said distilled water having:
- between about 6.4 grams and about 7.6 grams of sodium chloride;
- between about 0.2 gram and about 0.4 gram of potassium chloride;
- between about 0.1 gram and about 0.4 gram of calcium chloride;
- between about 0.2 gram and about 0.4 gram of magnesium sulphate;
- between about 0.1 gram and about 0.6 gram of monobasic sodium phosphate;
- between about 3.0 grams and about 7.5 grams of dextrose;
- between about 3.0 grams and about 6.0 grams of sodium citrate;
- and
- between about 2.0 grams and about 4.2 grams of sodium bicarbonate;
- said platelet storage medium being isotonic and having a pH in a range of between about 6.8 and about 7.4.
A process for preserving platelets in a sterile, plasma-free platelet storage medium comprising:
- preparing a physiologically compatible, aqueous electrolyte solution, one liter of said electrolyte solution having:
- between about 3.0 grams and about 7.5 grams of dextrose;
- between about 3.0 grams and about 6.0 grams of sodium citrate;
- and
- between about 2.0 grams and about 4.2 grams of sodium bicarbonate;
- suspending platelets in said platelet storage medium, said platelet storage medium being isotonic and having a pH in a range of between about 6.8 and about 7.4, whereby a substantial concentration of said platelets remain viable for at least about 14 days at a temperature of at least about 22.degree. C.
Dependencies are inferred from the claim text.