# US 4,692,328 A · Biologically useful polymer preparations

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- Number: US 4,692,328 A
- Document ID: US4692328A
- Status: Granted
- Kind: A
- Application number: 06/780,162
- Filed: 1985-09-24
- Granted: 1987-09-08
- Earliest claimed: 1985-09-24
- Assignees: Dynatech Corporation
- Inventors: Judith P. Kitchell; Stanton R. de Riel
- Web page: https://patentgrep.com/patent/US4692328A

## CPC

- A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene}
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61L 15/225: {Mixtures of macromolecular compounds}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.

## Claims

### Claim 1

A biologically useful polymer preparation prepared by
A. mixing a first solution comprising 20-60% (weight per volume) copolymer comprising vinyl pyrrolidone and allylamine in a ratio of 10 parts by weight vinyl pyrrolidone to 0-1 part by weight allylamine with a second solution comprising glutaraldehyde to give a final concentration of 0.04-3.6% (weight per volume) glutaraldehyde; and
B. forming a film from the mixture of step A.

### Claim 2 (depends on 1)

A biologically useful polymer preparation according to claim 1 wherein said first solution further comprises 0.05 to 0.1% by weight fumaryl chloride.

### Claim 3 (depends on 1)

A biologically useful polymer preparation according to claim 1, wherein said first solution further includes pharmaceutically active agents which will diffuse from the coating to skin covered by the coating.

### Claim 4 (depends on 1)

A polymer prepartation according to claim 1 for use as an electrically funcitonal electrode, wherein said first solution further includes electrolytes to provide electrical conductivity.

### Claim 5 (depends on 1)

A biologically useful polymer preparation according to claim 1, effective in the regulation of mositure loss from injured or burned skin, wherein the thickness of said film is related to moisture loss from said film.

### Claim 6 (depends on 1)

A polymer preparation according to claim 1 wherein said first solution further includes pharmaceutically active agents which may be delivered from the film through iontophoresis into and through intact or injured skin.