Anti-tumor halo bicyclo alkanones
AssigneeCBD Corporation
InventorsWalter J. Kasha, Chantal S. Burnison
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Abstract
Potent tumor inhibitors are prepared which are compounds of the formula: ##STR1## wherein Q is CO, CH(OH) or C(OH)CH.sub.3, M.sub.1 is halogen, M.sub.2 is halogen or hydrogen, c is one or two p is 0 or 1, and one of X and X' is H and the other is hydroxy-C.sup.2-9 alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sup.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl or (C.sub.1-2 -alkyl)oxycarbonyl-C.sup.2-9 -alkyl.
Claims21
A compound of the formula ##STR39## wherein Q is CO or CH(0R),
- R is hydrogen or methyl,
- M.sub.1 is halogen,
- M.sub.2 is halogen or hydrogen,
- c is one or two
- p is 0 or 1, and
- one of X and X' is H and the other is hydroxy-C.sup.2-9 alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sup.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl or (C.sub.1-2 -alkyl)oxycarbonyl-C.sup.2-9 -alkyl.
A pharmaceutical composition for inhibition of tumors which contains an effective dose of a compound of the formula ##STR41## wherein Q is CO or CH(OH),
- M.sub.1 is halogen,
- M.sub.2 is halogen or hydrogen,
- c is one or two
- p is 0 or 1, and
- one of X and X' is H and the other is hydroxy-C.sup.2-9 alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sup.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl or (C.sub.1-2 -alkyl)oxycarbonyl-C.sup.2-9 -alkyl. and a pharmaceutically acceptable carrier.
A method for inhibiting tumors in a mammal which comprises administration of an effective inhibitory dose of a compound of the formula:
- ##STR43## wherein Q is CO or CH(OH),
- M.sub.1 is halogen,
- M.sub.2 is halogen or hydrogen,
- c is one or two
- p is 0 or 1
- and one of X and X' is H and the other is hydroxy-C.sup.2-9 alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sup.2-9 -alkyl or oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl or (C.sub.1-2 -alkyl)oxycarbonyl-C.sup.2-9 -alkyl.
Dependencies are inferred from the claim text.