Oxygenated alkyl substituted bicyclo alkanes
AssigneeCBD Corporation
InventorsWalter J. Kasha, Chantal S. Burnison
Life of this patent
Estimating the term…
Abstract
Anti-androgenic composition compound of the formula ##STR1## wherein Q is CO, CH(OR), CR(OH), or CR (OC)-lower alkyl); R is H, or C.sup.1-2 -alkyl; X is hydroxyalkyl, methoxy-C.sup.2-11 -alkyl, ethoxy-C.sup.2-11 -alkyl or oxo-C.sup.2-11 -alkyl, formyl-C.sup.2-11 -alkyl, carboxy-C.sup.2-11 -alkyl or (C.sub.1-2 -alkyl) oxycarbonyl-C.sup.2-11 -alkyl; c is 1 or 2; p or w are 0, 1 or 2 and the sum of p and w is 1 to 4; and a pharmaceutically acceptable salt thereof.
Claims19
A method of blocking androgen receptor sites in a mammal which comprises applying to said sites an effective anti-androgenic dose of a compound of the formula ##STR51## wherein Q is CO, CH(OR), or CR(OH), R being H or C.sup.1-2 -alkyl;
- X is hydroxy-C.sup.2-9 -alkyl, methoxy-C.sup.2-9 -alkyl, ethoxy-C.sub.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl, or (C.sup.1-2 -alkyl) oxycarbonyl-C.sup.2-9 -alkyl,
- c is 1 or 2;
- p and w are 0, 1, or 2 and the sum of p and w is 1 to 4;
- or a pharmaceutically aceptable salt thereof.
A method of controlling a microorganism which has androgen receptor sites whereby androgen is taken into the system of the microorganism, which method comprises blocking said androgen receptor sites by administering to said microorganism an effective anti-androgenic dose of a compound of the formula:
- ##STR53## wherein Q is CO, CH(OR), or CR(OH), R being H or C.sup.1-2 -alkyl;
- X is hydroxy-C.sup.2-9 -alkyl, methoxy-C.sup.2-9 -alkyl, ethyoxyC.sup.2-9 -alkyl, oxo-C.sup.2-9 -alkyl, formyl-C.sup.2-9 -alkyl, carboxy-C.sup.2-9 -alkyl, or (C.sup.1-2 -alkyl) oxycarbonyl-C.sup.2-9 -alkyl,
- c, is 1 or 2;
- p and w are 0,1, or 2 and the sum of p and w is 1 to 4;
- or a pharmaceutically acceptable salt thereof by contacting said anti-androgenic agent with said microorganism, whereby androgen receptor sites are blocked, thereby blocking the uptake of androgen by said microorganism.
Dependencies are inferred from the claim text.