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US 4,689,320 AGranted
Method for inhibiting propagation of virus and anti-viral agent
OwnerAkira Kajiinventor
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OwnerAkira Kajiinventor
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Described is a method for inhibiting propagation of virus which comprises delivering one or more oligodeoxynucleotides or polydeoxynucleotides to a place where a messenger RNA (mRNA) generated on propagation of the virus exists, characterized in that the oligodeoxynucleotides or polydeoxynucleotides are identical in DNA sequence with a portion of the structure of DNA hybridizable to the mRNA, the structure being capable of hybridizing to the mRNA. Also described is an anti-viral agent which comprises an effective amount of one or more oligodeoxynucleotides or polydeoxynucleotides with a conventional liquid vehicle or excipient, characterized in that the oligodeoxynucleotides or polydeoxynucleotides are identical in DNA sequence with a portion of the structure of DNA hybridizable to an mRNA generated on propagation of the virus, the structure being capable of hybridizing to the mRNA. The method and the agent can widely be applied to the treatment of viral diseases.
A pharmaceutical composition, consisting essentially of
A method for treating herpes virus infections which comprises applying to a subject an effective antiviral amount of a pharmaceutical composition consisting essentially of an effective antiviral amount of an oligonucleotide or polydeoxynucleotide which has a sequence which is identical to a portion of DNA which has a hybridizable to messenger RNA of herpes virus, said oligodeoxynucleotide or polydeoxynucleotide being capable of hybridizing to said messenger RNA;
A method for treating a virus infection which comprises applying to a subject an effective antiviral amount of a pharmaceutical composition consisting essentially of an effective antiviral amount of an oligodeoxynucleotide or polydeoxynucleotide which has a sequence which is identical to a portion of DNA which is hybridizable to messenger RNA of a virus selected from the group consisting of adeno virus, vaccinia virus, influenza virus, rhino virus and polio virus, said oligodeoxynucleotide or polydeoxynucleotide being capable of hybridizing to said messenger RNA and a pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.