Oral composition containing antibodies to Bacteroides gingivalis
AssigneeLion Corporation
InventorsTatsuo Kiyoshige, Yasuo Kikuchi, Ichiro Takazoe, Katsuji Okuda
Life of this patent
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Abstract
An oral composition which prevents periodontal disease such as gingivitis, periodontitis and alveolar pyorrhoea through the prevention of the colonization of Bacteroides gingivalis comprises an antibody obtained by immunizing a mammal with an antigen selected from Bacteroides gingivalis, its pilus and capsule fractions.
Claims31
A dentifrice composition suitable for application to the mouth, comprising:
- an effective amount to suppress the intraoral colonization of Bacteroides gingivalis of an antibody obtained by immunizing a mammalian animal with an immunologically effective amount of at least one antigen selected from the group consisting of Bacteroides gingivalis, a pilus fraction of Bacteroides gingivalis and a capsule fraction of Bacteroides gingivalis;
- 5 to 95% by weight of an abrasive;
- and
- an orally acceptable carrier.
A method for treating periodontal disease in mammals caused by Bacteroides gingivalis which comprises applying to the mouth of a mammal an effective amount of the composition comprising:
- an effective amount to suppress the intraoral colonization of Bacteroides gingivalis of an antibody obtained by immunizing a mammalian animal with an immunologically effective amount of at least one antigen selected from the group consisting of Bacteroides gingivalis, a pilus fraction of Bacteroides gingivalis and a capsule fraction of Bacteroides gingivalis;
- and
- an orally acceptable carrier to suppress the growth of Bacteroides gingivalis.
An oral composition suitable for application to the mouth, comprising:
- an effective amount to suppress the intraoral colonization of Bacteroides gingivalis of an antibody obtained by immunizing a mammal selected from the group consisting of a rabbit, goat, sheet, horse and cow with at least one antigen selected from the group consisting of Bacteroides gingivalis, its pilus and capsule fractions wherein said effective amount is 0.0002 to 10% by weight of the composition;
- 5 to 95% by weight of the composition of an abrasive;
- and
- an orally acceptable carrier.
A method for treating periodontal disease in mammals caused by Bacteroides gingivalis which comprises applying to the mouth of a mammal an effective amount of a composition comprising:
- an effective amount to suppress the intraoral colonization of Bacteroides gingivalis of an antibody obtained by immunizing a mammal selected from the group consisting of a rabbit, goat, sheep, horse and cow with at least one antigen selected from the group consisting of Bacteroides gingivalis, its pilus and capsule fractions;
- and an orally acceptable carrier to suppress the growth of Bacteroides gingivalis.
An oral composition suitable for application to the mouth, comprising:
- an effective amount to suppress the intraoral colonization of Bacteroides gingivalis of a purified serum or milk antibody obtained by immunizing a mammalian animal with an immunologically effective amount of at least one antigen selected from the group consisting of Bacteroides gingivalis, a pilus fraction of Bacteroides gingivalis and a capsule fraction of Bacteroides gingivalis;
- and an orally acceptable carrier, said oral composition being in the form of a dentifrice, a liquid refrigerant, a solid refrigerant, a dental paste, a gingival massage cream, a gargle tablet or a dairy product.
An oral composition suitable for application to the mouth, comprising:
- an effective amount to suppress the intraoral colonization of Bacteroides gingivalis of an anti-pilus fraction of Bacteroides gingivalis antibody or an anti-capsule fraction of Bacteroides gingivalis antibody;
- and
- an orally acceptable carrier.
A method for treating periodontal disease in mammals caused by Bacteroides gingivalis which comprises applying to the mouth of a mammal an effective amount of the composition of claim 32.
Dependencies are inferred from the claim text.