Reduced peptides which inhibit gastric secretion, process for their preparation and pharmaceutical compositions in which they are present
AssigneesSanofi, Centre National de la Recherche Scientifque (CNRS)
InventorsJean Martinez, Jean-Pierre Bali, Richard Magous, Bertrand Castro, Henri Demarne
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Abstract
The invention relates to the peptides of the formula: ##STR1## in which: R.sub.1 represents hydrogen or a protecting group for the amine group, such as t-butoxycarbonyl, benzyloxycarbonyl or lower alkanoyl groups; X represents beta-alanine glycine or a direct bond between R.sub.1 and the amine group; and R.sub.2 represents a group chosen from: ##STR2## corresponding to the side chains of the natural amino acid leucine, methionine and norleucine. These peptides inhibit gastric secretion.
Claims11
A peptide corresponding to the general formula:
- ##STR26## in which:
- R.sub.1 represents hydrogen or a protecting group for the amine group;
- benzyloxycarbonyl
- X represents beta-alanine, glycine or a direct bond between R.sub.1 and the amine group;
- and
- R.sub.2 represents a group chosen from:
- ##STR27## corresponding to the side chains of the natural amino acids leucine, methionine and norleucine, and also its salts with inorganic or organic bases.
Dependencies are inferred from the claim text.