Preparation of methyl ketones
AssigneeBayer Aktiengesellschaft
InventorsReinhard Lantzsch, Hans-Ludwig Elbe
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Abstract
A process for the preparation of a methyl ketone of the formula ##STR1## in which R.sup.1 is alkyl, alkenyl, alkinyl, optionally substituted aryl or optionally substituted heteroaryl, R.sup.2 is alkyl, R.sup.3 is alkyl or R.sup.2 and R.sup.3, together with the carbon atom to which they are bonded, from a cycloalkyl ring, comprising reacting a methyl sec.-alkyl ketone of the formula ##STR2## with a halide of the formula R.sup.1 --CH.sub.2 --X in which X is halogen, in the presence of a base, a diluent, and a phase-transfer catalyst.
Claims6
A process for the preparation of a methyl ketone of the formula ##STR26## in which R.sup.1 is alkyl, having 1 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkinyl having 2 to 4 carbon atoms, phenyl optionally substituted by halogen, alkyl having 1 to 4 carbon atoms, alkoxy or alkylthio, each having 1 to 2 carbon atoms, as well as halogenoalkyl, halogenoalkoxy and halogenoalkylthio, each having 1 to 2 carbon atoms or 1 to 5 identical or different halogen atoms, or dialkylamino having 1 to 4 carbon atoms in each alkyl part;
- or also R.sup.1 represents 5-membered or 6-membered heteroaryl selected from the group consisting of pyridal, pyrimidinyl, furyl or thienyl, wherein each heteroaryl is unsubstituted or optionally substituted by alkyl having 1 to 2 carbon atoms or by halogen, comprising reacting at a temperature between about 0.degree. and 150.degree. C. a methyl sec.-alkyl ketone of the formula ##STR27## with a halide of the formula
- R.sup.1 --CH.sub.2 --X
- in which
- X is halogen,
- in the presence of a base, a diluent, and a phase-transfer catalyst.
Dependencies are inferred from the claim text.