US 4,686,085 A · Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Abstract

A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.

Claims10

Dependent claims

An oxygenation apparatus for use in treating hypoxic ischemic neurologic tissue comprising:

(a) reservoir means for containing synthetic organic oxygenatable fluid which is physiologically acceptable to neurologic tissue;
(b) oxygenator means connected in fluid communication with said fluid in said reservoir means for oxygenating said fluid;
(c) first flow control means for establishing a circulation of said fluid between said oxygenator means and said reservoir means at a first preselected rate;
(d) injection means connected in fluid communication with said fluid in said reservoir means for injecting said fluid into the extravascular cerebrospinal pathway;
(e) second flow control means for establishing flow of said fluid through said injection means at a second preselected rate;
and
(f) withdrawal means for withdrawing of fluid from said cerebrospinal pathway.

4 more elements

Dependencies are inferred from the claim text.

Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Life of this patent

Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Life of this patent

Abstract

Claims10