Antibiotic A80190-producing Actinomadura oligospora and process
AssigneeEli Lilly and Company
InventorsRobert L. Hamill, Raymond C. Yao
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Abstract
New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomadura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
Claims5
A process for producing antibiotic A80190 which comprises cultivating Actinomadura oligospora NRRL 15877, or an A80190-producing mutant thereof, in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a recoverable amount of antibiotic A80190 is produced.
A biologically purified culture of the microorganism Actinomadura oligospora NRRL or an A80190-producing mutant thereof.
Dependencies are inferred from the claim text.