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US 4,677,120 AGranted
Topical prodrugs for treatment of acne and skin diseases
AssigneeMolecular Design International, Inc.
InventorsHarlie A. Parish, William P. Purcell
Life of this patent
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Abstract
Esters and amides of 13-cis-retinoic acid are disclosed which are used for the treatment of acne and skin diseases.
Claims14
A compound of the formula:
- ##STR17## wherein R is a member of the group consisting of:
- ##STR18## wherein X is a member of the group consisting of:
- --H, --F, --Cl, --Br, --I, --OH, --OR', ##STR19## --CN, --NO.sub.2, --NH.sub.2, --NHR', and --NR'.sub.2 ;
- wherein n is a number from 1 to 5;
- wherein R' is a member of the group consisting of lower alkyls ranging from C.sub.1 to C.sub.6 ;
- and p1 wherein R" is a member of the group consisting of:
- ##STR20## --OR', ##STR21## and --R'.
4 more elements
A pharmaceutical composition for the treatment of acne which comprises:
- an effective acne-treatment amount of an acne-treating compound of the formula:
- ##STR23## wherein R is a member of the group consisting of:
- ##STR24## wherein X is a member of the group consisting of:
- --H, --F, --Cl, --Br, --I, --OH, --OR, --OR', ##STR25## --CN, --NO.sub.2, --NH.sub.2, --NHR', and --NR.sub.2 ';
- wherein n is a number from 1 to 5;
- wherein R' is a member of the group consisting of lower alkyls ranging from C.sub.1 to C.sub.6 ;
- and
- wherein R" is a member of the group consisting of ##STR26## --OR', ##STR27## and --R';
- admixed with a pharmaceutically-acceptable vehicle.
6 more elements
A method for treating acne in a subject requiring such treatment which comprises:
- topical application to the acne site of said subject of a pharmaceutical composition which comprises an effective acne-treatment amount of a compound of the formula:
- ##STR29## wherein R is a member of the group consisting of:
- ##STR30## wherein X is a member of the group consisting of:
- --H, --F, --Cl, --Br, --I, --OH, --OR, --OR', ##STR31## --CN, --NO.sub.2, --NH.sub.2, --NHR', and --NR.sub.2 ';
- wherein n is a number from 1 to 5;
- wherein R' is a member of the group consisting of lower alkyls ranging from C.sub.1 to C.sub.6 ;
- and
- wherein R" is a member of the group consisting of ##STR32## --OR', ##STR33## and --R';
- admixed with a pharmaceutically-acceptable topical vehicle.
6 more elements
A method for treating acne in a subject requiring such treatment which comprises:
- oral application to said subject of an effective acne-treatment amount of a compound of the formula:
- ##STR35## wherein R is a member of the group consisting of:
- ##STR36## wherein X is a member of the group consisting of:
- --H, --F, --Cl, --Br, --I, --OH, --OR, --OR', ##STR37## --CN, --NO.sub.2, --NH.sub.2, --NHR', and --NR.sub.2 ';
- wherein n is a number from 1 to 5;
- wherein R' is a member of the group consisting of lower alkyls ranging from C.sub.1 to C.sub.6 ;
- and
- wherein R" is a member of the group consisting of ##STR38## --OR', ##STR39## and --R';
- admixed with a pharmaceutically acceptable oral vehicle.
6 more elements
Dependencies are inferred from the claim text.