Fractionation/purification of plasma by ion exchange chromatography
AssigneesRhone-Poulenc Recherches, Institut Merieux
InventorsAdrien Dromard, Michel Exertier, Claude Rollin, Jean-Louis Tayot, Michel Tardy
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Abstract
The plasma proteins contained in a plasma solution thereof are chromatographically fractioned, e.g., to obtain a high purity therapeutic grade albumin product, by successively contacting said plasma solution with at least one anion exchanger and at least one cation exchanger in fixed bed chromatography columns, the contact and exchange medium of chromatography therein also comprising a plurality of at least partially hydrophobic support particulates and a plurality of hydrophilic ion exchanger support particulates.
Claims25
In a process for the chromatographic fractionation of the plasma proteins contained in a plasma solution thereof by successively contacting said plasma solution with at least one anion exchanger and at least one cation exchanger, the improvement which comprises contacting said plasma solution with a contact and exchange chromatography medium comprising a plurality of at least partially hydrophobic support particulates and a plurality of hydrophilic ion exchanger support particulates.
Dependencies are inferred from the claim text.