Microencapsulation of water soluble active polypeptides
AssigneeSyntex (U.S.A.) Inc.
InventorsJohn S. Kent, Danny H. Lewis, Lynda M. Sanders, Thomas R. Tice
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Abstract
This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.
Claims18
A pharmaceutical composition designed for sustained release of a luteinizing hormone-releasing hormone (LHRH) analog, prepared in microcapsule form, wherein the composition comprises at least one luteinizing hormone-releasing hormone analog or a pharmaceutically acceptable salt thereof in an amount between 0.01 and 40.0 weight percent, and a poly(lactide-co-glycolide) polymer having a molar ratio of 75:25 to 40:60, said polymer being present in an amount between 99.9 and 60 weight percent, which composition exhibits sustained release of an effective amount of the luteinizing hormone-releasing hormone analog over a period of at least one month.
Dependencies are inferred from the claim text.