Drug compositions and methods of applying same

A composition of matter for use in the treatment of a malady of a living being, said composition comprising:

• (a) a medical treatment dose defined by a multitude of drug units,
• (b) each drug unit including a microcapsule made of a degradable material which biodegrades in the presence of a body fluid and which may be administered to a living being to expose the microcapsules of such dose to body fluid as the drug units travel through the body to a select site within the body,
• (c) a small quantity of a drug useful in the treatment of said malady by reacting with tissue of the body at said select site and contained within each of said microcapsules,
• (d) at least one biologically engineered, targeting monoclonal antibody, targeted to a specific type of antigen associated with a specific cancer,
• (e) said antibody being bonded to an outer surface of said microcapsules and operable to attach the drug units to respective cancer cells by travelling through the body fluid of a living being to whom said dose is administered,
• (f) said biodegradable material being operable in the presence of the body fluid to degrade and release the drug contents of said microcapsules after a time delay once said drug units have entered the body and said drug units are targeted to a select cancer site in the body of the living being to whom said medical dose has been administered.

A composition of matter for use in a drug delivery system and adapted to be disposed adjacent select tissue in a living being for selectively treating said tissue, said composition comprising:

• (a) a multitude of drug units each including respective drug containers and each defining at least one enclosed volume for containing a medicinal material,
• (b) a small quantity of select medicinal material contained within the enclosed volumes of said containers, and
• (c) said drug units including an activatable material for causing their respective drug containers to release their contents upon activation of said activatable material after each drug unit is disposed adjacent select tissue within a living being,
• (d) each of said drug units being effective to permit the medicinal material it contains to be delivered directly to said select tissue without directly affecting body tissue located distal from said select tissue,
• (e) said activatable material comprising a quantity of a normally inactive nuclide material retained by each of said containers,
• (f) said nuclide material being operable to become radioactive to release the medicinal material from the container when a beam of activating radiation is directed thereat from outside a body of a living being in which said containers are disposed.

A composition of matter for use in a drug delivery system and adapted to be disposed adjacent select tissue in a living being for selectively treating said tissue, said composition comprising:

• (a) a multitude of drug units each including respective drug containers and each defining at least one enclosed volume for containing a medicinal material,
• (b) a small quantity of a select medicinal material contained within the enclosed volumes of said containers,
• (c) said drug units including an activatable material for causing their respective drug containers to release their contents upon activation of said activatable material after each drug unit is disposed adjacent select tissue within a living being,
• (d) each of said drug units being operable to target the medicinal material it contains to permit it to be delivered directly to select tissue without directly contacting or affecting body tissue located distal from select tissue,
• (e) said activatable material comprising a biodegradable material used to form the containers enclosing the medicinal material therein,
• (f) said biodegradable material being operable to degrade in the presence of a body fluid to release the medicinal material contained by the container for uptake by the select tissue of the body of a living being in which said containers are disposed.

A composition of matter for use in a drug delivery system and adapted to be disposed adjacent select tissue in a living being for selectively treating said tissue, said composition comprising:

• (a) a multitude of drug units each including a respective drug container and each defining at least one enclosed volume for containing a medicinal material,
• (b) a small quantity of a select medicinal material contained within the enclosed volumes of said containers,
• (c) said drug units including an activatable material for causing their respective drug containers to release their contents upon activation of said activatable material after each drug unit is disposed adjacent select tissue within a living being,
• (d) each of said drug units being effective to permit the medicinal material it contains to be delivered directly to select tissue without directly contacting or affecting body tissue located distal from said select tissue, and
• (e) targeting material defined by at least one targeting unit targeted to a specific type of antigen associated with a specific cancer,
• (f) said targeting material being bonded to an outer surface of the drug containers and operable to attach the drug units to respective cancer cells by travelling through the body fluid of a living being in which said containers are disposed.