Electrochemical cell sensor for continuous short-term use in tissues and blood
AssigneeThe Regents of the University of California
InventorDavid A. Gough
Life of this patent
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Abstract
An electrochemical cell sensor for monitoring oxidizable enzyme substrates in biological fluids situated in a housing and suitable for implantation in the body, including at least one oxygen or hydrogen peroxide sensing electrode containing a suitable oxidase enzyme, a reference electrode, and a counter electrode all in communication with biological fluids through one or more openings in the walls of the housing.
Claims24
An electrochemical cell sensor capable of being implanted into an animal body comprising:
- a housing with an opening or openings in the wall of said housing;
- said housing comprising a hollow needle composed of platinum or stainless steel, and said housing and said opening or openings covered with a layer of porous biocompatible material;
- electrode means situated in said housing and in fluid communication via said opening or openings with fluids present in said animal body and responsive to enzyme substrates or products present in said fluid;
- and a means for relating said response of said electrode means to the concentration of said enzyme substrates or products present in said fluids.
An electrochemical cell sensor capable of being implanted in an animal body comprising an electrically conductive hollow needle housing with one or more openings in the walls of said electrically conductive hollow needle housing;
- an electrode means situated in said housing and in fluid communication via said opening or openings with fluids present in said animal body and responsive to enzyme substrates or products in said fluids, said electrode means comprising four (4) electrodes,
- an enzyme substrate or product dependent sensing electrode, composed of a noble metal and in communication with an oxidase enzyme, an enzyme substrate independent oxygen-sensing electrode composed of a noble metal, a reference electrode composed of silver/silver chloride and a common counter electrode being said hollow needle housing;
- and a
- means for differentially regulating the accessibility of said enzyme substrates or products to said electrode means, and a means for relating said response of said electrode means to the concentration of said said enzyme substrates or products present in said fluids.
An electrochemical cell sensor capable of being implanted into an animal body comprising:
- a hollow needle housing with one opening in the walls of said housing,
- an electrode means situated in said housing and in fluid communication via said opening with fluids present in said animal body and responsive to enzyme substrates present in said fluids,
- a means for supplying oxygen to said electrode means, and
- a means for relating said response of said electrode means to the concentration of said enzyme substrates in said fluids.
Dependencies are inferred from the claim text.