1.alpha.,2.alpha.-methylene-6-methylene- and 6.alpha.-methylpregnenes, their preparation and pharmaceutical use
AssigneeSchering Corporation
InventorsKlaus Annen, Henry Laurent, Walter Elger, Rudolf Wiechert, Helmut Hofmeister, Michael Topert
Life of this patent
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Abstract
1.alpha.,2.alpha.-methylene-6-methylene- and 6.alpha.-methylpregnenes of Formula I ##STR1## wherein A is ##STR2## and R is a hydrogen atom, an acyl group, or an alkoxymethyl group are strong antiandrogens, and suitable for the topical treatment of seborrhea, acne, alopecia, and hirsutism.
Claims10
A 1.alpha.,2.alpha.-methylene-6-methylenepregnene of the formula ##STR7## wherein A is ##STR8## and R is hydrogen, an acyl group of a C.sub.1-7 hydrocarbon aliphatic or aromatic carboxylic acid, or (C.sub.1-3 -alkoxy) methyl.
A method of achieving a topical antiandrogenic effect in a patient comprising administering to the patient an amount of a 1.alpha.,2.alpha.-methylene-6-methylene- or 6.alpha.-methyl-pregnene of the formula ##STR9## wherein A is ##STR10## and R is hydrogen, an acyl group of a C.sub.1-7 hydrocarbon aliphatic or aromatic carboxylic acid, or (C.sub.1-3 -alkoxy) methyl effective as an antiandrogenic agent.
Dependencies are inferred from the claim text.