Hemoglobin combined with a poly(alkylene oxide)
AssigneeAjinomoto Co., Inc.
InventorsKeiji Iwasaki, Yuji Iwashita, Taketoshi Okami
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Abstract
There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure: --CH.sub.2 --O--(CH.sub.2)--CONH--Hb wherein Hb represents said hemoglobin and n represents a positive integer, preferably 1 to 7. The modified hemoglobin is an effective oxygen carrier and can therefore be used as a blood substitute.
Claims11
A modified hemoglobin, comprising:
- hemoglobin bonded to the terminal groups of poly(alkylene oxide) through the amino groups in said hemoglobin by a linking group of the structure:
- --CH.sub.2 --O--(CH.sub.2).sub.n --CONH--Hb, wherein Hb represents said hemoglobin and n is a positive integer.
An effective oxygen carrier for use as a blood substitute, comprising:
- a modified hemoglobin, as the oxygen carrying ingredient, which has the structure of hemoglobin bonded to the terminal groups of poly(alkylene oxide) through the amino groups in said hemoglobin by a linking group of the structure:
- --CH.sub.2 --O--(CH.sub.2).sub.n --CONH--Hb, wherein Hb represents said hemoglobin and n is a positive integer.
A method of enhancing the oxygen carrying ability of blood, comprising:
- injecting into the circulatory system of a subject, a modified hemoglobin bonded to the terminal groups of poly(alkylene oxide) through the amino groups in said hemoglobin by a linking group of the structure:
- --CH.sub.2 --O--(CH.sub.2).sub.n --CONH--Hb, wherein Hb represents said hemoglobin and n is a positive integer.
Dependencies are inferred from the claim text.