Container for blood and blood components
AssigneeMiles Laboratories, Inc.
InventorsBruce E. Barnes, Mohan S. Mahal
Life of this patent
Estimating the term…
Loading patent…
AssigneeMiles Laboratories, Inc.
InventorsBruce E. Barnes, Mohan S. Mahal
Estimating the term…
A blood container for storage of blood and blood components is disclosed. The invention comprises a blood container and a multiple blood bag system which includes a donor bag and one or more satellite bags connected by flexible tubing. The blood bag is made of polyvinyl chloride (PVC) plasticized with a blend of plasticizers comprising a plasticizer resistant to blood extraction such as a triester of trimellitic acid and a 7-10 carbon alcohol and a blood extractable plasticizer such as a dioctyl phthalate or dioctyl adipate and is suitable for long term storage of whole blood, red cells and platelets. The blood container is made of a thin material which contains a plasticizer composition extractable at much lower levels by blood or plasma than conventional phalate plasticized PVC. Blood and blood components processed or stored in the blood bags will exhibit relatively low levels of contamination by plasticizer.
A container for storage of blood or blood components which comprises a flexible, translucent, heat-sterilizable, heat-sealable polymeric substance comprising polyvinyl-chloride plasticized with a mixture comprising a blood extractable plasticizer being present in an amount of 5 to 25 percent by weight, and a plasticizer resistant to blood extraction being present in an amount of 20 to 40 percent by weight, the total amount of plasticizer mixture being sufficient to enhance the gas permeability of the polymeric substance to provide clinically effective levels of platelets stored therein for a period of at least five days and the blood extractable plasticizer being present in an amount sufficient to provide clinically effective levels of unhemolyzed red cells stored therein for a period of at least 35 days without being significantly extracted and without raising the level of extracted plasticizer mixture above about 10 ppm in blood or red cell concentrates stored therein for 35 days, whereby the blood or red cell concentrates are substantially free of said plasticizer mixture.
Dependencies are inferred from the claim text.