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US 4,668,769 AGranted
Oxa- and azahomocyclostatine polypeptides
OwnerDennis J. Hooverinventor
Life of this patent
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Abstract
Polypeptides and derivatives thereof containing oxa- and azahomocyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
Claims15
A compound of the formula ##STR15## and a pharmaceutically acceptable salt thereof, wherein R.sup.1 is selected from the group consisting of hydrogen and methyl;
- X is selected from the group consisting of oxygen, amino, alkylamino having one to four carbon atoms, cyclohexylmethylamino, benzylamino, omega-aminohexylamino and methoxycarbonylmethylamino;
- and R.sup.2 is selected from the group consisting of LysPhe, LysPhe-methyl ester, LysPhe amide, LysSta, amino, alkylamino having one to four carbon atoms, alkyl having three to four carbon atoms, 4-imidazolylethylamine, omega-aminohexylamino, benzyloxy, omegacyanopentylamino and a reduced IlePhe of the formula ##STR16## wherein R.sub.3 is selected from the group consisting of hydrogen, omega-aminohexyl and omega-cyanopentyl.
A compound of the formula ##STR18## and a pharmaceutically acceptable salt thereof, wherein R.sub.4 is alkyl of three to four carbon atoms.
Dependencies are inferred from the claim text.