Surgical cements
AssigneeUniversity of Dayton
InventorPraphulla K. Bajpai
Life of this patent
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Abstract
Surgical bone repair cements useful in medical and/or dental applications comprising a bone substitute such as hydroxyapatite, tricalcium phosphate or aluminocalcium oxide-phosphorous pentoxide ceramic and a polyfunctional carboxylic acid such as malic acid, .alpha.-ketoglutaric acid or citric acid as a setting agent.
Claims21
A surgical cement consisting essentially of a bone substitute and a water soluble, polyfunctional carboxylic acid, said acid containing 2 to 10 carbon atoms and being present in an amount of about 25 to 100 parts by weight per 100 parts by weight of said bone substitute.
A surgical cement consisting essentially of 100 parts by weight of a bone substitute, 25 to 100 parts by weight of a water soluble polyfunctional carboxylic acid having to 10 carbon atoms, and up to 10 parts by weight of a polymeric material, said bone substitute being a resorbable or non-resorbable material selected from the group consisting of beta-tricalcium phosphate, hydroxyapatite, milled freeze dried bone, calcium aluminate, calcium phosphate and alumino-calcium oxide-phosphorous pentoxide ceramic, and said polyfunctional carboxylic acid contains 2 to 6 carbon atoms and 2 to 4 carboxyl groups and exhibits a pK less than 5.61 and greater than 3.08.
A surgical cement consisting essentially of 100 parts by weight of a bone substitute, 25 to 100 parts by weight of a water soluble polyfunctional carboxylic acid having up to 10 carbon atoms, and up to 10 parts by weight of a polymeric material, said bone substitute being a resorbable or non-resorbable material selected from the group consisting of beta-tricalcium phosphate, hydroxyapatite, milled freeze dried bone, calcium aluminate, calcium phosphate and alumino-calcium oxide-phosphorous pentoxide ceramic, and said polyfunctional carboxylic acid containing 2 to 6 carbon atoms and 2 to 4 carboxyl groups and exhibiting a pK less than 5.61 and greater than 3.08 and said polymeric material being selected from the group consisting of polylactic acid, polyacrylic acid and polymethacrylic acid.
Dependencies are inferred from the claim text.