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US 4,665,079 AGranted
Antibacterial agents
AssigneeWarner-Lambert Company
InventorsTownley P. Culbertson, John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
Life of this patent
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Abstract
Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
Claims21
A compound of the formula ##STR49## wherein is Z is --Z'.about.(CR.sub.5 R.sub.6)n"NR.sub.3 R.sub.4 in which Z' is ##STR50## X is CH, CF, C--OH, C--O-alkyl having from one to three carbon atoms, C--NH-alkyl having from one to three carbon atoms;
- n" is zero or one;
- R.sub.1 is hydrogen, alkyl having from one to six carbon atoms or a cation;
- R.sub.2 is alkyl having from one to four carbon atoms, vinyl, haloalkyl or hydroxyalkyl having from two to four carbon atoms or cycloalkyl having three to six carbon atoms;
- R.sub.3 is hydrogen, alkyl having from one to four carbon atoms or cycloalkyl having three to six carbon atoms;
- R.sub.4 is hydrogen, alkyl from one to four carbon atoms, or R.sub.7 CO wherein R.sub.7 is alkyl having from one to four carbon atoms or alkoxy having from one to four carbon atoms;
- R.sub.5 is hydrogen or alkyl having from one to three carbon atoms;
- R.sub.6 is hydrogen or alkyl having from one to three carbon atoms, or a pharmaceutically acceptable acid addition or base salt thereof.
4 more elements
Dependencies are inferred from the claim text.