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US 4,663,161 AGranted
Liposome methods and compositions
OwnerRaphael J. Mannino, Susan G. Fogeriteinventors
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Abstract
The present disclosure relates to novel liposome compositions and methods for their preparation. Utilization of the present invention provides an efficient reconstitution of membrane proteins into large (0.1 to 2 micron diameter) phospholipid vesicles with a large, internal aqueous space. The method has been exemplified with the use of glycoproteins of influenza (A/PR8/34) and Sendai (parainfluenza type I) viruses.
Claims9
A membrane protein containing phospholipid vesicle composition characterized in having
- (A) a large internal aqueous space;
- (B) a size distribution in the range of from about 0.1 to about 2 microns;
- (C) the bilayer of said vesicles containing membrane proteins substantially integrated in the lipid bilayer morphologically indistinguishable from those formed on the native organism;
- and
- (D) the biological activity of said membrane protein is essentially preserved.
2 more elements
Dependencies are inferred from the claim text.