Topical treatment and composition
AssigneeBeecham Group Limited
InventorsMichael J. Thomson, Frank R. Mangan
Life of this patent
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Abstract
Pharmaceutical compositions with comprise a compound of the formula (I): ##STR1## wherein X is a chlorine or bromine atom or a methoxyl, methylthio or alkyl group of 1-4 carbon atoms; Y is a --CHR.sub.1 --CH.sub.2 -- or --CR.sub.1 .dbd.CH-- group where R.sub.1 is a hydrogen atom or a methyl group and A is a CHOH or CO group, and a pharmaceutically acceptable carrier selected from the group of creams, ointments, lotions, gels, aerosols, sprays, liniments and gel sticks. The compositions possess systemic anti-inflammatory activity when administered topically.
Claims16
A topically effective anti-inflammatory pharmaceutical composition which comprises a topically effective anti-inflammatory amount of a compound of the formula (I):
- ##STR4## wherein X is a chlorine or bromine atom or a methoxyl, methylthio or alkyl group of 1-4 carbon atoms;
- Y is a --CHR.sub.1 --CH.sub.2 -- or --CR.sub.1 .dbd.CH-- group where R.sub.1 is a hydrogen atom or a methyl group and A is a CHOH or CO group, and a pharmaceutically acceptable carrier, said composition being selected from the group consisting of creams, ointments, lotions, gels, aerosol formulations, spray formulations, liniments and gel sticks.
A method for treatment or prophylaxis of inflammation in mammals comprising topically administering to a mammal an anti-inflammatory topically effective amount of a compound of formula (I) ##STR5## wherein X is a chlorine or bromine atom or a methoxyl, methylthio or alkyl group of 1-4 carbon atoms;
- Y is a --CHR.sub.1 --CH.sub.2 -- or --CR.sub.1 .dbd.CH-- group where R.sub.1 is a hydrogen atom or a methyl group and A is a CHOH or CO group.
Dependencies are inferred from the claim text.