Coupling agents for radiolabeled antibody fragments
AssigneeMallinckrodt Inc.
InventorsRobert A. Nicolotti, Richard T. Dean
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Abstract
Bifunctional coupling agent for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.
Claims5
A coupling agent for joining a paramagnetic or radionuclide metal ion with an antibody Fab' fragment comprising a compound of the formula:
- ##STR8## wherein R is selected from --(CH.sub.2).sub.n -- in which n is an integer from 1 to 20 and phenylene and R' is a group which is capable of chelating a radionuclide metal ion.
A coupling agent for joining a paramagnetic or radionuclide metal ion with an antibody Fab' fragment comprising a compound of the formula:
- ##STR9##
A coupling agent for joining a paramagnetic or radionuclide metal ion with an antibody Fab' fragment comprising a compound of the formula:
- ##STR10##
Dependencies are inferred from the claim text.