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US 4,650,907 AGranted
Nonaromatic fluoroallylamine MAO inhibitors
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsPhilippe Bey, Michael G. Palfreyman, Ian A. McDonald
Life of this patent
Estimating the term…
Abstract
Novel nonaromatic fluoroallylamines are potent MAO inhibitors and at low dose selectively inhibit MAO-B. They are useful in the treatment of depression and coadministered with L-dopa, in the treatment of Parkinsonism.
Claims16
A Fluoroallylamine of the formula ##STR13## wherein R is hydrogen or a (C.sub.1 -C.sub.4) alkyl;
- n and m are each either zero or 1;
- A and B are each selected from ##STR14## x+y+z is 0 to 16 but y must be greater than 2 when A and B are each selected from O, S and SO.sub.2 ;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each a hydrogen or a (C.sub.1 14 C.sub.4) alkyl or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.