Anti-allergic hydroxybiphenyl compounds
AssigneeKabushiki Kaisha Tsmurajuntendo
InventorsAkihide Kooda, Itsuo Nishioka, Takeshi Nishiyori, Shoji Yahara
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Abstract
New hydroxybiphenyl compounds of the general formula: ##STR1## wherein R.sub.1 stands for a hydrogen atom or a hydroxyl group, R.sub.2 for a hydrogen atom or a hydroxyl group, R.sub.3 for a hydroxyl group, a group of the formula --CH.sub.2 --CH.dbd.CH.sub.2 or a group of the formula --CH.dbd.CH--CHO, R.sub.4 for a hydrogen atom or a group of the formula ##STR2## and R.sub.5 for a hydroxyl group or a group of the formula ##STR3## These compounds are obtained by extraction of "Tokoboku", i.e. dried cortex of Magnolia officinalis which belongs to the family Magnoliaceae. They are useful as pharmaceuticals or intermediates therefor, in particular as anti-allergics.
Claims12
A pharmaceutical composition containing as an active ingredient an effective anti-allergic amount of an hydroxybiphenyl compound of the formula:
- ##STR13## wherein one of R.sub.1 and R.sub.2 is a hydrogen atom and the other is a hydroxyl group and R.sub.3 is a hydroxyl group or a group of the formula --CH.dbd.CH--CHO and a carrier therefor.
A method for treating delayed hypersensitivity reactions comprising administering to a host an effective anti-allergic amount of an hydroxybiphenyl compound of the formula:
- ##STR14## wherein one of R.sub.1 and R.sub.2 is a hydrogen atom and the other is a hydroxyl group and R.sub.3 is a hydroxyl group or a group of the formula --CH.dbd.CH--CHO.
A pharmaceutical composition containing as an active ingredient an effective anti-allergic amount of an hydroxybiphenyl compound of the formula:
- ##STR15## or of the formula:
- ##STR16## and a carrier therefor.
A method for treating delayed hypersensitivity reactions comprising administering to a host an effective anti-allergic amount of an hydroxybiphenyl compound of the formula:
- ##STR17## or of the formula:
- ##STR18##
Dependencies are inferred from the claim text.