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US 4,650,759 AGranted
Method of producing L-carnitine
AssigneeAjinomoto Co., Inc.
InventorsKenzo Yokozeki, Koji Kubota
Life of this patent
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Abstract
A method for producing L-carnitine which involves contacting crotonbetaine or a non-toxic, soluble salt of this compound with a microorganism or an enzyme fraction of this microorganism which is capable of converting crotonbetaine or its salts into L-carnitine. The conversion is conducted in an aqueous medium under conditions suitable for production of L-carnitine.
Claims6
A method for producing L-carnitine, which comprises:
- contacting crotonbetaine or a salt thereof and a microorganism or microorganism-derived fraction which is competent to transform crotonbetaine or salts thereof into L-carnitine in an aqueous medium under conditions suitable for the formation of L-carnitine, and
- recovering L-carnitine,
- wherein the microorganism is selected from the group consisting of:
- Alcaligenes marshallii:
- ATCC 21030,
- Acinetobacter lwoffi:
- ATCC 9036,
- Aglobacterium tumefaciens:
- ATCC 4452,
- Arthrobacter parraffineus:
- ATCC 15590,
- Acromobacter viscosus:
- ATCC 12448,
- Azotobacter chroococcum:
- ATCC 9043,
- Aeromonas punctata:
- ATCC 11163,
- Bacillus laterosporus:
- ATCC 64,
- Brevibacterium linens:
- ATCC 8377,
- Corynebacterium xerosis:
- ATCC 373,
- Citrobacter intermedius:
- IFO 13539,
- Cellulomonas flavigena:
- ATCC 15724,
- Erwinea carotovora:
- IFO 3380,
- Enterobacter agglomurans:
- ATCC 12287
- Flavibacterium ferrugineum:
- ATCC 13524,
- Hafnia alvei:
- ATCC 9760,
- Kurthia zopfii:
- ATCC 6900,
- Klebsiella pneumoniae:
- ATCC 9621,
- Mycoplana bullata:
- ATCC 4278,
- Micrococcus varians:
- ATCC 399,
- Microbacterium ammoniaphilum:
- ATCC 15354,
- Pseudomonas chlororaphis:
- ATCC 9446,
- Proteus mirabilis:
- ATCC 15290,
- Salmonella gallinarum:
- ATCC 9184,
- Seratia liquefaciens:
- ATCC 14460,
- Staphylococcus aureus:
- IFO 3060,
- Vibrio metschnikovii:
- ATCC 7708,
- Xanthomonas campestris:
- ATCC 8721,
- Zuglear ramigena:
- ATCC 19544,
- Protaminobacter alboflavus:
- IFO 3707,
- Thiobacillus perometabolis:
- ATCC 23370,
- Streptomyces olivaceus:
- IFO 3200,
- Nocardia corallina:
- IFO 3338,
- Candida lipolytica:
- IFO 0746,
- Cryptococcus neoformans:
- IFO 0608,
- Debaryomyces hansenii:
- IFO 0080,
- Deotrichum candidum:
- IFO 4602,
- Hansenula anomala:
- IFO 0122,
- Hanseniaspora valbyensis:
- IFO 0683,
- Kluyveromyces fragils:
- IFO 0541,
- Lipomyces lipofer:
- IFO 0673,
- Klokera japonica:
- IFO 0151,
- Pihia membranaefaciens:
- IFO 0460,
- Pachysolen tannophilus:
- IFO 1007,
- Rhodotorula glutinis:
- IFO 0395,
- Lodderomyces elongisporus:
- IFO 1676,
- Saccharomyces cerevisiae:
- IFO 2003,
- Trigonopsis variabilis:
- IFO 0755, and
- Torulopsis famate:
- ATCC 12790.
98 more elements
Dependencies are inferred from the claim text.