Synergistic cytotoxic composition
AssigneeGenentech, Inc.
InventorsBharat B. Aggarwal, Sang He Lee
Life of this patent
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Abstract
Compositions comprising an interferon and a cytotoxic protein designated tumor necrosis factor exhibit a synergistic cytotoxic effect on tumor cells.
Claims8
A cell free composition suitable for the treatment of tumors comprising (a) a human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE and (b) a human interferon, which composition is free of lymphotoxin.
A composition suitable for the treatment of tumors consisting essentially of human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE and a human interferon.
A method suitable for the treatment of tumors comprising administering a human interferon to a tumor cell within an animal, followed by administering to the cell human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE, in amounts effective to cause cytolysis of said tumor cell.
Dependencies are inferred from the claim text.