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US 4,647,585 AGranted
Bicycloheptane substituted ethers
AssigneeE. R. Squibb & Sons, Inc.
InventorsMelanie J. Loots, Steven E. Hall, Peter W. Sprague
Life of this patent
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Abstract
Bicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein X is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
Claims18
A compound of the structure ##STR58## including all stereoisomers thereof, wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --;
- n is 0 to 8;
- p is 0 or 1;
- X is O or ##STR59## wherein q is 0, 1 or 2;
- R is H, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane;
- and R.sup.1 is lower alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, lower alkenyl containing 2 to 12 carbons or lower alkynyl containing 2 to 12 carbons, wherein lower alkyl or alkyl alone or as part of another group contains 1 to 12 carbons and is unsubstituted or is substituted with halo, CF.sub.3 alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl or alkylcycloalkyl;
- aryl alone or as part of another group contains 6 to 10 carbons in the ring portion and is unsubstituted or is substituted with 1 or 2 lower alkyl groups, 1 or 2 halogens and/or 1 or 2 lower alkoxy groups;
- and
- cycloalkyl alone or as part of another group contains 3 to 12 carbons and is unsubstituted or is substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups and/or 1 or 2 lower alkoxy groups.
5 more elements
Dependencies are inferred from the claim text.