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US 4,647,283 AGranted
Implantable biological tissue and process for preparation thereof
AssigneeAmerican Hospital Supply Corporation
InventorsAlain Carpentier, Sophie Carpentier, Aws S. Nashef
Life of this patent
Estimating the term…
Abstract
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.
Claims14
A process for treating biological tissue prior to implantation which comprises the steps of:
- a. fixing said tissue under tissue fixing conditions;
- b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation;
- said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation;
- and
- c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.
2 more elements
A method of increasing the durability of implantable biological tissue which comprises the steps of:
- a. fixing said tissue under tissue fixing conditions;
- b. contacting said fixed tissue with a solution effective in reducing calcification of said tissue after implantation;
- said calcification reducing solution comprising an amount of a calcium-binding competing divalent cation effective in reducing calcification and having a level of phosphate decreased to an amount effective in reducing calcification of tissue after implantation;
- and
- c. maintaining the tissue in contact with a solution having said reduced level of phosphate to a time just prior to implantation.
2 more elements
Dependencies are inferred from the claim text.