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US 4,645,666 AGranted
Vaccine for bluetongue disease employing platinum compounds
AssigneeThe Regents of the University of California
InventorsJarue S. Manning, Giorgio Poli
Life of this patent
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Abstract
Vaccine prepared by inactivation of non-enveloped virus with cis-diamino chelated platinous halide in presence of an effective amount of a detergent. Method of inactivation particularly applicable employing a non-ionic detergent in inactivating a double stranded RNA virus.
Claims17
A method for preparing a vaccine by inactivating a non-enveloped virus which comprises:
- contacting said virus with an inactivating amount of a cis-diamine chelated platinous halide and a small but effective amount of a non-ionic detergent for a sufficient time to inactivate said virus and retain intact virion particles for preparing said vaccine.
A method for preparing a vaccine by inactivating a non-enveloped double-stranded RNA virus which comprises:
- contacting said virus with an aqueous medium containing an inactivating amount of cis-diamine chelated platinous halide and from about 0.001 to 0.75 weight percent of a non-ionic detergent for a sufficient time to inactivate said virus and retain intact virion particles.
Dependencies are inferred from the claim text.