Increasing labeling efficiency by forming diagnostic agent in the presence of ascorbic acid or the like
AssigneeNihon Medi-Physics Co., Ltd.
InventorsKeietsu Takahashi, Nobuo Ueda, Masaaki Hazue, Akira Yokoyama, Yoshiro Ohmomo
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Abstract
A radioactive diagnostic agent having high labeling efficiency, prepared by bringing an aqueous solution of a radioactive metallic element contaminated with a non-radioactive metallic ions into contact with a non-radioactive carrier comprising a carrier substance having a chelate-forming property and optionally a physiologically active substance chemically bonded thereto, at least one of said aqueous solution and said non-radioactive carrier comprising at least one reductive material chosen from ascorbic acid and erythrobic acid, and their salts and esters.
Claims8
A method for enhancing the labeling efficiency of a non-radioactive carrier with a radioactive metallic element other than technetium-99m in the presence of a non-radioactive metallic element as an impurity, said non-radioactive carrier comprising deferoxamine or its combined product with a physiologically active substance, said method comprising the step of contacting the non-radioactive carrier with the radioactive metallic element in the presence of a non-toxic amount of a reductive material selected from the group consisting of ascorbic acid, erythorbic acid, and their salts and esters.
Dependencies are inferred from the claim text.