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US 4,642,242 AGranted
Permanently bonded antithrombogenic polyurethane surface
AssigneeBecton, Dickinson and Company
InventorsDonald D. Solomon, Charles W. McGary, Vincent J. Pascarella
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Abstract
An antithrombogenic polyurethane polymer being bound to a support substrate wherein the antithrombogenic agent is reacted through an aldehyde group with an amine functionality of a polyurethane-urea to form the covalently bonded antithrombogenic material.
Claims7
A process for imparting antithrombogenic activity to polyurethane polymer materials, which comprises:
- a. treating the surface of a solid support with a solution of a protonated amine rich polyurethane-urea so that the polyurethane-urea is bonded to the support substrate;
- b. removing solvent from the treated substrate to form a layer of the polyurethane-urea upon the support substrate;
- c. activating the amine functionality on the polyurethane-urea with an alkaline buffer to form free amine groups;
- and
- d. reacting the free amine groups with an aldehyde containing antithrombogenic agent to covalently bond the antithrombogenic agent to the polyurethane-urea in the presence of a reducing agent.
2 more elements
Dependencies are inferred from the claim text.