Gadolinium chelates as NMR contrast agents
AssigneeBoard of Regents, The University of Texas System
InventorA. Dean Sherry
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Abstract
Chelates of gadolinium with 1,4,7-triazacyclononane-N,N',N"-triacetate; 1,4,7,10-tetrazacyclododecane-N,N',N'"tetraacetate; and 1,5,9-triazacyclododecane-N,N',N"-triacetate are useful as NMR contrast agents.
Claims4
A method of enhancing NMR contrast in a living subject, comprising administering internally to the subject an effective amount of a contrast agent which comprises a chelate of gadolinium with a compound selected from the group consisting of DOTRA, DOTA, NOTA, and salts thereof.
A method of enhancing NMR contrast in a living subject, comprising administering internally to the subject an effective amount of a contrast agent which comprises a chelate of gadolinium with DOTRA or a salt thereof.
A method of enhancing NMR contrast in a living subject, comprising administering internally to the subject an effective amount of a contrast agent which comprises a chelate of gadolinium with DOTA or a salt thereof.
A method of enhancing NMR contrast in a living subject, comprising administering internally to the subject an effective amount of a contrast agent which comprises a chelate of gadolinium with NOTA or a salt thereof.
Dependencies are inferred from the claim text.