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US 4,638,045 AGranted
Non-peptide polyamino acid bioerodible polymers
AssigneeMassachusetts Institute of Technology
InventorsJoachim Kohn, Robert S. Langer
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Abstract
A novel bioerodible polymeric composition is provided comprising a plurality of monomer units of two or three amino acids which are polymerized via hydrolytically labile bonds at their respective side chains rather than at the amino or carboxylic acid terminals by amide bonds. Such polymers are useful for controlled release applications in vivo and in vitro for delivery of a wide variety of biologically and pharmacologically active ligands.
Claims14
A bioerodible polymer formed by polymerizing a dipeptide formed exclusively of L-alpha amino acids of the formula:
- ##STR20## or by polymerizing a tripeptide formed exclusively of L-alpha amino acids of the formula:
- ##STR21## wherein at least one of Z or Y is an amine or carboxyl protecting group and wherein polymerization is effected through at least one of R.sub.1, R.sub.2 or R.sub.3 without the formation of additional peptide bonds through the terminal, amine and carboxyl groups of said dipeptide or tripeptide.
Dependencies are inferred from the claim text.