3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsKazuo Kubo, Yasuo Isomura, Shuichi Sakamoto, Hiroshige Homma
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Abstract
Novel 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds shown by the formula ##STR1## wherein .circle.Het -- represents a specific heterocyclic group and the salts thereof. The compounds have an anti-inflammatory, an anti-pyretic, an analgesic, an anti-arthritic, and an immunoregulatory activity. Hence, they are particularly useful as an antirheumatics.
Claims16
A 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compound represented by the formula ##STR107## wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a phenyl or naphthyl lower alkyl group, a phenyl group, a naphthyl group, a lower alkoxy-substituted phenyl or naphthyl group, or the group shown by --O--Z, ##STR108## or --NH--Z wherein Z represents a hydrogen atom, a lower alkyl group, a carboxy lower alkyl group, a lower alkoxycarbonyl lower alkyl group, a phenyl or naphthyl lower alkyl group, a phenyl group, or a naphthyl group and n represents 0, 1, or 2;
- and A represents an oxygen atom, a sulfur atom, an imino group, a lower alkylimino group, or a 3,5-di-tert-butyl-4-hydroxyphenacylimino group ##STR109## and salts thereof.
Dependencies are inferred from the claim text.