Novel amidine compound
AssigneeTorii & Co., Ltd.
InventorsSetsuro Fujii, Toyoo Nakayama, Shigeki Nunomura, Ryoji Matsui, Shin-ichi Watanabe, Kimio Sudo, Toshiyuki Okutome, Masateru Kurumi, Yojiro Sakurai, Takuo Aoyama
Life of this patent
Estimating the term…
Abstract
Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.
Claims1
Amidine compounds of formula (I) ##STR86## wherein R.sub.1, R.sub.2 and R.sub.3 represent each a hydrogen atom, R.sub.4, halogen, NO.sub.2, ##STR87## R.sub.4 represents a C.sub.1 to C.sub.4 straight or branched chain alkyl group;
- R.sub.5 represents a hydrogen atom, a C.sub.1 to C.sub.4 straight or branched chain alkyl or benzyl group;
- R.sub.6 represents a C.sub.1 to C.sub.4 straight or branched chain alkyl group, ##STR88## R.sub.7 represents a C.sub.1 to C.sub.4 straight or branched chain alkyl group or ##STR89## R.sub.8 represents a hydrogen atom, NO.sub.2 or a guanidino group;
- X represents a single bond, --(CH.sub.2).sub.2 -- or --CH.dbd.CH--;
- n is 0 to 4;
- R.sub.9 and R.sub.10 each represent a hydrogen atom or R.sub.12 CO--,
- wherein R.sub.12 represents a C.sub.1 to C.sub.4 straight or branched chain alkyl group, a benzyloxycarbonyl or t-butoxycarbonyl group;
- Z represents a single bond, a C.sub.1 to C.sub.4 straight or branched chain alkylene, a C.sub.1 to C.sub.4 straight or branched chain alkenylene or a C.sub.1 to C.sub.4 straight or branched chain alkynylene group;
- and
- A represents ##STR90## and pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.