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US 4,634,708 AGranted
Indolophenanthridines useful as dopaminergic and analgesic agents
AssigneeSandoz Ltd.
InventorsAlexander Hagenbach, Max P. Seiler, Hans J. Wuthrich
Life of this patent
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Abstract
4,6,6a,7,8,12b-hexahydro-indolo[4,3-ab]phenanthridines are useful as dopaminergic and analgesic agents.
Claims17
A compound of formula I ##STR16## wherein R.sub.1 and R.sub.3 independently are hydrogen, (C.sub.1-4)alkyl, (C.sub.3-5)alkenyl wherein the double bond is not adjacent to the nitrogen atom, (C.sub.3-6)cycloalkyl(C.sub.1-3)alkyl, phenyl(C.sub.1-3)alkyl optionally substituted in the phenyl ring by (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, hydroxy or halogen, or 2- or 3-furyl(C.sub.1-3)alkyl,
- R.sub.2 is hydrogen, chlorine, bromine or methyl,
- X.sub.1 and X.sub.2 independently are hydrogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, hydroxy, halogen or trifluoromethyl,
- in free base or acid addition salt form.
Dependencies are inferred from the claim text.