Carboxyalkenamidocephalosporins
AssigneeShionogi & Co., Ltd.
InventorYoshio Hamashima
Life of this patent
Estimating the term…
Abstract
An antibacterial 7beta-(carboxyalkenoyl)amino-3-cephem-4-carboxylic acid represented by the following formula: ##STR1## (wherein R is aryl or a heterocyclic group; R.sup.1 is hydrogen or halogen; R.sup.2 is a single bond, alkylene, or thiaalkylene; R.sup.3 is a hydrogen atom or carboxy modifying group; R.sup.4 is hydrogen or methoxy; R.sup.5 is hydrogen or a 3-substituent of cephalosporins; R.sup.6 is a hydrogen atom or carboxy modifying group; and X is oxygen, sulfur, or sulfinyl) a pharmaceutical composition containing the same, and a method for treating a bacterial infection with the same.
Claims18
A compound of the formula ##STR100## wherein R is 2-aminothiazol-4-yl the amino group of which is unprotected or protected with a protecting group,
- R.sup.3 is (1) hydrogen, (2) a pharmacologically acceptable salt forming group, (3) phthalidyl, (4) phenacyl, (5) C.sub.2-7 alkenyl, (6) diphenylmethyl, (7) trityl, (8) phenylalkyl of 7 to 15 carbon atoms said group being unsubstituted or substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 2 carbon atoms, nitro, amino or hydroxy or (9) a lower alkyl group,
- R.sup.5 is hydrogen, methyl, vinyl, cyanovinyl, trifluoropropenyl, methoxymethyl, carbamoyloxymethyl, methylthiomethyl, cyanomethylthiomethyl, thiadiazolylthiomethyl, triazolylthiomethyl, aminomethylthiadiazolylthiomethyl, aminothiadiazolylthiomethyl, methoxy, fluoroethylthio, trifluoroethylthio, or halogen, and
- R.sup.6 is (1) hydrogen, (2) a pharmacologically acceptable salt forming atom or group, (3) a lower alkyl group, (4) a lower alkenyl group (5) phthalidyl, (6) phenacyl, (7) diphenylmethyl, (8) trityl or (9) phenylalkyl of 7 to 15 carbon atoms said group being unsubstituted or substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 2 carbon atoms, nitro, amino or hydroxy.
Dependencies are inferred from the claim text.