Process for the production of human mono-clonal antibodies
AssigneeSandoz Ltd.
InventorLars Oestberg
Life of this patent
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Abstract
Hybridoma cell line made by fusing a xenogeneic hybridoma cell to a genetically compatible substance producing cell. Such hybridomas can be used i.a. for the production of antibodies.
Claims21
A hybridoma cell line comprising an immortalizing cell fused to a cell producing a predetermined human antibody, the immortalizing cell comprising a xenogeneic hybridoma cell fused from an immortalizing cell and a non-transformed partner cell, said human antibody producing cell being genetically compatible with said non-transformed partner cell.
A (mouse.times.human).times.human hybridoma cell line capable of producing human antibodies of a predetermined specificity wherein both human cells are not transformed.
A stable (mouse.times.human).times.human hybridoma cell line capable of producing human antibodies of a predetermined specificity wherein each human cell is non-transformed.
Dependencies are inferred from the claim text.