Reagent and method for radioimaging leukocytes
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDavid A. Goodwin, Claude F. Meares
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Abstract
Leukocytes are radioimmunoimaged by injecting patients with an immunoreactive nonleukocidal conjugate of an anti-leukocyte antibody and a gamma-emitting radioactive metal chelate, waiting for the conjugate to localize on the leukocytes, injecting the patient with an antibody to the conjugate to clear the blood of background nonlocalized conjugate, and visualizing the leukocytes by scintillation scanning.
Claims16
A leukocyte radioimmunoimaging reagent comprising an immunoreactive nonleukocidal conjugate of an antibody to a leukocyte membrane determinant and a bifunctional phenyl or benzyl derivatine of EDTA or DTPA chelated with a radioactive metal.
A kit for use in radioimmunoimaging leukocytes in a patient comprising in:
- (a) a first container containing conjugate of an antibody to a nontumor-specific membrane determinant of the leukocytes and a bifunctional benzyl or phenyl derivative of EDTA or DTPA;
- and
- (b) a second container containing an antibody to the conjugate that does not cross react with endogenous components of the patient's blood.
Dependencies are inferred from the claim text.