# US 4,632,980 A · Ozone decontamination of blood and blood products

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 4,632,980 A
- Document ID: US4632980A
- Status: Granted
- Kind: A
- Application number: 06/719,187
- Filed: 1985-04-03
- Granted: 1986-12-30
- Earliest claimed: 1985-04-03
- Assignees: Immunologics
- Inventors: Yuan C. Zee; David C. Bolton
- Web page: https://patentgrep.com/patent/US4632980A

## CPC

- A61L 2/20: Gaseous substances, e.g. vapours
- A61L 2/202: Ozone
- A61L 2103/05: Living organisms or biological materials
- A61M 1/1698: {Blood oxygenators with or without heat-exchangers (intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00)}
- A61M 1/32: Oxygenators without membranes
- A61M 2202/0216: Ozone
- Y10S 530/829: Blood
- Y10S 530/83: Plasma; serum
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Blood and proteinaceous blood products employed for their physiological and/or immunological properties are free of viable enveloped viruses by treatment with low levels of ozone, levels at which substantially all of the physiological and/or immunological activity is retained.

## Claims

### Claim 1

A method for freeing blood and blood components of viable enveloped viruses while retaining the physiological characteristics of the blood or blood component, said method comprising:
contacting said blood or blood product in an aqueous medium with an enveloped virus inactivating amount of ozone under mild conditions for a sufficient time to inactivate all enveloped viruses present; and
isolating the blood or blood component free of viable enveloped viruses.

### Claim 2 (depends on 1)

A method according to claim 1, wherein said contacting is at a temperature in the range of 4.degree. to 37.degree. C. and at an ozone concentration of 1 to 100 ppm.

### Claim 3 (depends on 2)

A method according to claim 2, wherein said blood or blood component is contacted as a thin film.

### Claim 4 (depends on 2)

A method according to claim 2, wherein the contacting is for a duration of 0.5 hr to 4 days.

### Claim 5 (depends on 2)

A method according to claim 2, wherein blood is contacted with ozone.

### Claim 6 (depends on 2)

A method according to claim 2, wherein an aqueous solution of a blood component is contacted with ozone.