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US 4,631,149 AGranted
Antiviral eudistomins from a marine tunicate
AssigneeUniversity of Illinois
InventorsKenneth L. Rinehart, Jr., Gary C. Harbour, Jun'ichi Kobayashi
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Abstract
The subject invention concerns novel and useful antiviral compounds referred to as eudistomins. These compounds are obtainable from well-known and available marine organisms. Their utility is as antiviral agents as well as antibacterial and antitumor agents in some cases.
Claims1
A compound selected from the group consisting of eudistomins C, E, K, L, F, and the acylates of C and E having the formula II:
- wherein the variables for each eudistomin are defined as follows:
- ______________________________________ Eudistomin R R.sub.1 R.sub.2 R.sub.31 ______________________________________ C H OH Br H E Br OH H H K H H Br H L H Br H H F H OH Br --COCH.sub.2 OH C (diacetyl) H --OCOCH.sub.3 Br --COCH.sub.3 E (diacetyl) Br --OCOCH.sub.3 H --COCH.sub.3 ______________________________________
- or other carboxylic acylates or pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.