Erodible matrix for sustained release bioactive composition
AssigneeZetachron, Inc.
InventorWallace C. Snipes
Life of this patent
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Abstract
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises said biologically active compound dispersed in a bioerodible matrix, the matrix comprising a mixture of 5 to 95% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in the aqueous liquid. Dosage forms comprising the erodible matrix are prepared by molding, particularly by injection molding.
Claims83
A composition erodible by an aqueous liquid comprising
- 5 to 95% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in said aqueous liquid, the molecular structure of said amphiphilic compound having a lipophilic portion and a hydrophilic portion.
A sustained release composition for releasing a biologically active compound into its surrounding environment comprising said biologically active compound dispersed in a matrix which, when contacted with an aqueous liquid, erodes progressively, said matrix comprising a mixture of
- 5 to 95% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in said aqueous liquid, the molecular structure of said amphiphilic compound having a lipophilic portion and a hydrophilic portion.
A sustained release composition for releasing a biologically active compound into its surrounding environment comprising a pharmaceutically active compound or non-toxic pharmaceutically acceptable salt of said pharmaceutically active compound dispersed in a matrix which, when contacted with an aqueous liquid, erodes progressively, said matrix comprising a mixture of
- 5 to 95% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in said aqueous liquid, the molecular structure of said amphiphilic compound having a lipophilic portion and a hydrophilic portion.
A sustained release composition for releasing an ecologically active compound into its surrounding environment comprising said ecologically active compound dispersed in a matrix which, when contacted with an aqueous liquid, erodes progressively, said matrix comprising a mixture of
- 5 to 95% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in said aqueous liquid, the molecular structure of said amphiphilic compound having a lipophilic portion and a hydrophilic portion.
A sustained release dosage form for releasing a biologically active compound into an aqueous liquid environment comprising a non-porous solid erodible matrix having dispersed therein a biologically active compound, said matrix comprising a mixture of
- 5 to 95% by weight of a polyethylene glycol having a molecular weight of from about 1000 to about 20,000, and
- 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in said aqueous liquid, the molecular structure of said amphiphilic compound having a lipophilic portion and a hydrophilic portion.
Dependencies are inferred from the claim text.