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US 4,623,660 AGranted
Triphenylalkene derivatives
AssigneeImperial Chemical Industries PLC
InventorDora N. Richardson
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Abstract
The disclosure relates to 1-p-aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phenylalk-1-ene derivatives, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-oestrogenic activity and are useful in the treatment of anovulatory infertility and the breast tumors. Representative of the compounds disclosed is 1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1-p-hydroxyphenyl-2-p-tolylbu t-1-ene.
Claims7
An alkene derivative of the formula:
- ##STR17## wherein either R.sup.1 is a hydrogen atom or a lower alkyl radical and R.sup.2 is a lower alkyl radical, or R.sup.1 and R.sup.2 are joined together with the adjacent nitrogen atom to form a heterocyclic radical;
- R.sup.3 is a halogen atom or a lower alkyl radical;
- R.sup.4 is a halogen atom, or a hydroxy or lower alkyl radical, or is the buta-1,3-dienyl radical such that together with the benzene ring it forms a naphthyl radical;
- and n is 2 or a pharmaceutically-acceptable acid-addition salt thereof.
1 more element
Dependencies are inferred from the claim text.