Method of homogenizing dispersions of hydrated lipidic lamellar phases and suspensions obtained by the said method
AssigneeParfums Christian Dior
InventorsGerard Redziniak, Alain Meybeck
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Abstract
The invention concerns a method of homogenizing dispersions of hydrated lipidic lamellar phases and suspensions obtained thereby which can be applied particularly to the making of products intended for cosmetic, pharmaceutical and medical uses. The method consists in dispersing in a dispersion liquid a lipidic phase or a lipidic lamellar phase containing one or several amphiphilic lipids and then in homogenizing the said dispersion by feeding the same under a pressure comprised between 10,000 and 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element arranged in the section of the orifice adjustably, against the flow of the dispersion.
Claims29
A method for obtaining a homogenized suspension of hydrated lipidic lamellar phases entrapping a liquid, comprising the successive steps of:
- (a) providing an appropriate liquid,
- (b) dispersing in said liquid, a lipidic phase or a lipidic lamellar phase containing at least one amphiphilic lipid, thereby obtaining a dispersion of said lipidic phase or lipidic lamellar phase in said liquid, and
- (c) directly feeding said dispersion under a feeding pressure ranging between about 10,000 kPa and about 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element adjustably arranged in the section of said orifice, against the flow of said dispersion,
- thereby encapsulating said liquid within lipidic lamellar particles of said lipidic lamellar phase by entrapping a part of said liquid within said lipidic lamellar particles and forming a suspension in homogenized form of said encapsulated particles in the remaining liquid, thus achieving a high rate of encapsulation of said liquid within said lipidic lamellar particles.
A method for obtaining a homogenized suspension of hydrated lipidic lamellar phases entrapping a liquid, comprising:
- (a) providing an appropriate aqueous liquid,
- (b) dispersing in said aqueous liquid, an appropriate amount of a lipidic phase or a lipidic lamellar phase containing at least one amphiphilic lipid, thereby obtaining a dispersion of said lipidic phase or lipidic lamellar phase in said liquid comprising from 50 to 99.0% of said liquid and from 50 to 0.1% of said lipidic or lipidic lamellar phase, and
- (c) directly feeding said dispersion under a feeding pressure ranging between about 10,000 kPa and about 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element adjustably arranged in the section of said orifice, against the flow of said dispersion,
- thereby encapsulating said liquid within lipidic lamellar particles of said lipidic lamellar phase by entrapping a part of said liquid within said lipidic lamellar particles and forming a suspension in homogenized form of said encapsulated particles in the remaining liquid, thus achieving a high rate of encapsulation of said liquid within said lipidic lamellar particles.
A method for obtaining a homogenized suspension of hydrated lipidic lamellar phases entrapping a liquid, comprising:
- (a) providing an appropriate aqueous liquid,
- (b) dispersing in said liquid, an appropriate amount of a hydrated lipidic lamellar phase containing at least one amphiphilic lipid, thereby obtaining a dispersion of said lipidic lamellar phase in said liquid comprising from 20 to 99.9% liquid and from 80 to 0.1% of said hydrated lipidic lamellar phase, and
- (c) directly feeding said dispersion under a feeding pressure ranging between about 10,000 kPa and about 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element adjustably arranged in the section of said orifice, against the flow of said dispersion,
- thereby encapsulating said liquid within lipidic lamellar particles of said lipidic lamellar phase by entrapping a part of said aqueous liquid within said lipidic lamellar particles and forming a suspension in homogenized form of said encapsulated particles in the remaining liquid, thus achieving a high rate of encapsulation of said aqueous liquid in said lipidic lamellar particles.
A method for obtaining a homogenized suspension of hydrated lipidic lamellar phases entrapping a liquid, comprising the successive steps of:
- (a) providing a liquid comprising a biologically active product,
- (b) dispersing in said liquid, a lipidic phase or a lipidic lamellar phase containing at least one amphiphilic lipid, thereby obtaining a dispersion of said lipidic phase or lipidic lamellar phase in said liquid, and
- (c) directly feeding said dispersion under a feeding pressure ranging between about 10,000 kPa and about 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element adjustably arranged in the section of said orifice, against the flow of said dispersion,
- thereby encapsulating said liquid within lipidic lamellar particles of said lipidic lamellar phase by entrapping a part of said liquid comprising said biologically active product within said lipidic lamellar particles and forming a suspension in homogenized form of said encapsulated particles in the remaining liquid, thus achieving a high rate of encapsulation of said liquid within said biologically active product within said lipidic lamellar particles.
A method for obtaining a homogenized suspension of hydrated lipidic lamellar phases entrapping a liquid, comprising the successive steps of:
- (a) providing a liquid comprising a product which possesses organoleptic properties,
- (b) dispersing in said liquid, a lipidic phase or a lipidic lamellar phase containing at least one amphiphilic lipid, thereby obtaining a dispersion of said lipidic phase or lipidic lamellar phase in said liquid, and
- (c) directly feeding said dispersion under a feeding pressure ranging between about 10,000 kPa and about 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element adjustably arranged in the section of said orifice, against the flow of said dispersion,
- thereby encapsulating said liquid within lipidic lamellar particles of said lipidic lamellar phase by entrapping a part of said liquid with said product which possesses organoleptic properties within said lipidic lamellar particles and forming a suspension in homogenized form of said encapsulated particles in the remaining liquid, thus achieving a high rate of encapsulation of said liquid comprising said product which possesses organoleptic properties within said lipidic lamellar particles.
A suspension of hydrated lipidic lamellar phases entrapping a liquid, in said liquid, obtained by dispersing in an appropriate liquid a lipidic phase or lipidic lamellar phase containing at least one amphiphilic lipid, thereby obtaining a dispersion of said lipidic phase or lipidic lamellar phase in said liquid, and then homogenizing said dispersion by directly feeding the same under a feeding pressure ranging between about 10,000 kPa and about 70,000 kPa into a passageway of small width defined between the walls of an orifice and the edges of an obturating element adjustably arranged in the section of said orifice, against the flow of said dispersion, thereby encapsulating said liquid within lipidic lamellar particles of said lipidic lamellar phase by entrapping a part of said liquid within said lipidic lamellar particles and forming a suspension in homogenized form of said encapsulated particles in the remaining liquid, thus achieving a high rate of encapsulation of said aqueous liquid within said lipidic lamellar particles, the size of said lipidic lamellar particles ranging between 30 and 150 nanometers.
Dependencies are inferred from the claim text.