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US 4,619,924 AGranted
2-alkylthiopenem derivatives
AssigneePfizer Inc.
InventorErnest S. Hamanaka
Life of this patent
Estimating the term…
Abstract
Certain 2-alkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals.
Claims24
A compound of the formula ##STR7## or a pharmaceutically-acceptable salt thereof, wherein:
- R is trans-1-oxo-3-thiolanyl, cis-1-oxo-3-thiolanyl, 1,1-dioxo-3-thiolanyl, trans-1-oxo-3-thianyl, cis-1-oxo-3-thianyl, trans-1-oxo-3-thiethanyl, 1,1-dioxo-4-thianyl, 4-thianyl, trans-1-oxo-4-thianyl, cis-1-oxo-4-thianyl, cis-1-oxo-3-thietanyl or 1-oxo-3-thiolanyl.
A compound of the formula ##STR8## wherein R.sub.1 is (2-methyl-2-propylcarbonyloxy)methyl, phthalidyl, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl, 1-(methylcarbonyloxy)-1-ethyl or 1-(ethoxycarbonyloxy)-1-ethyl;
- and R is 1-oxo-3-thiolanyl or cis-1-oxo-3-thiolanyl.
(2-Methyl-2-propylcarbonyloxy)methyl (5R,6S)-6-((R)-1-hydroxyethyl)-2-(1,1-dioxo-3-thiolanyl)thio-2-penem-3-car boxylate.
Dependencies are inferred from the claim text.