Tripeptide compounds containing pyroglutamic acid and tryptophan, process for their production and therapeutic applications
AssigneePolifarma S.p.A.
InventorsGiovanni Di Stazio, Vincenzo Politi, Andrea Margonelli, Giovanna De Luca, Mario Materazzi
Life of this patent
Estimating the term…
Abstract
Thirteen new tripeptides made from levorotatory amino acids are described, corresponding to the formula p--GLU--X--TRP X is a specific amino acid different from p-GLU and TRP, as well as a process for the preparation of these compounds, pharmaceutical formulations containing them and the use of these formulations as hypotensive and analgesic agents.
Claims10
Tripeptide compounds in a substantially pure form, formed by levorotatory amino acids of the formula
- p-GLU-X-TRP
- wherein X is a radical derived from an amino acid chosen from the group GLY, VAL, GLU, ASP, SER, ALA, PRO, LYS, ARG, ILE, LEU, bonded to p-GLU-TRP and by a peptide bond.
Lower alkyl tryptophan esters of tripeptide compounds formed by levorotatory amino acids of formula
- p-GLU-X-TRP
- wherein X is a radical derived from an amino acid chosen from the group GLY, VAL, GLU, ASP, SER, ALA, ASN, GLN, ILE, LEU, PRO, LYS and ARG, bonded to p-GLU-TRP and by a peptide bond.
A method of reducing tension and pain in mammals comprising administering to said mammals a hypotensive and analgesic amount of a tripeptide, made from levorotatory amino acids of formula
- p-GLU-X-TRP
- wherein X is a radical derived from an amino acid chosen from the group GLY, VAL, GLU, ASP, SER, ALA, ASN, GLN, ILE, LEU, PRO, LYS and ARG, bonded to p-GLU-TRP and by a peptide bond, or a lower alkyl tryptophan ester thereof.
A pharmaceutical composition comprising a hypotensive and analgesic effective amount of a tripeptide, made from levorotatory amino acids of formula
- p-GLU-X-TRP
- wherein is a radical derived from an amino acid chosen from the group GLY, VAL, GLU, ASP, SER, ALA, ASN, GLN, ILE, LEU, PRO, LYS and ARG, bonded to p-GLU-TRP and by a peptide bond, or a lower alkyl tryptophan ester thereof.
Dependencies are inferred from the claim text.