Disinfectant solution for contact lens
OwnerRichard F. Stockelinventor
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Abstract
An aqueous anti-microbial disinfectant solution for contact lenses contains an effective amount of an active ingredient which is an anti-microbial, organosilicon quaternary ammonium salt chemically bonded to a water soluble, high molecular weight organic polymer. The solution is non-toxic and non-irritating to the eye, and does not adsorb or penetrate into a contact lens.
Claims37
An aqueous solution for disinfecting soft contact lenses comprising the reaction product of an organosilicon quaternary ammonium salt of the formula:
- ##STR22## where Y is a hydrolyzable radical, which is alkoxy, or acyloxy;
- R is a monovalent hydrocarbon group, which is lower alkyl or phenyl;
- a is 0-2;
- Q is a divalent hydrocarbon radical, which is alkylene or phenylene;
- m is 1-20;
- R' is alkyl C.sub.1 -C.sub.18, aryl, alkaryl, or aralkyl;
- R" is lower alkyl;
- n is 9-17;
- X is monovalent inorganic or organic radical or group selected from the group consisting of halogen;
- triiodide;
- acyloxy;
- or YSO.sub.4, where Y is a monovalent hydrocarbon, hydrogen, and --(CH.sub.2 --).sub.x --COOR'", where x is at least 2 and R"' is a monovalent hydrocarbon group free of unsaturation with about 75-99 wt % of a water soluble organic polymer reactive with said hydrolyzable group and having a molecular weight sufficient to prevent the reaction product from being adsorbed into or penetrating the soft contact lens.
The reaction product, which is effective as a disinfectant particularly for soft contact lenses, which results from the reaction of
- (i) about 1-25 wt % of an anti-microbial organosilicon quaternary ammonium salt which has the formula:
- ##STR23## where:
- Y is a hydrolyzable radical;
- which is alkoxy or acyloxy;
- R is a monovalent hydrocarbon group which is lower alkyl or phenyl;
- a is 0-2;
- Q is a divalent hydrocarbon radical which is alkylene or phenylene;
- m is 1-20;
- R' is alkyl C.sub.1 -C.sub.18, aryl, alkaryl, or aralkyl;
- R" is lower alkyl;
- n is 9-17;
- X is a monovalent inorganic or organic radical or group selected from halogen, triiodide, acyloxy or YSO.sub.4 ;
- where Y is a monovalent hydrocarbon, hydrogen, or --(CH.sub.2).sub.x --COOR"', where x is at least 2, and R"' is a monovalent hydrocarbon group free of unsaturation;
- with:
- (ii) about 75-99 wt % of a water soluble organic polymer reactive with said hydrolyzable group and having a molecular weight sufficient to prevent the reaction product from being absorbed or penetrating a soft contact lens, wherein said polymer is selected from the group consisting of polyacrylamides, polymethacrylamides, polydiacetoneacrylamides, polyacrylic acids, polymethacrylic acids, polyhydroxy alkacrylates, polyhydroxyalkylmethacrylates, carboxymethylcellulose, hydroxymethylcellulose, polyaminoalkylacrylates, polyaminoalkylmethacrylates, polyamines, polyalkylene oxides, hydrophilic polyesters, hydrophilic polyamides, polyvinylpyrrolidone, polyvinylalchohol, polyethylene sulfonic acid and polystyrene sulfonic acid.
Dependencies are inferred from the claim text.